Diels Alder Reaction Virtual Lab Simulation | PraxiLabs

Diels Alder Reaction Virtual Lab Simulation

Chemistry | Organic Chemistry

As Featured In

General Aim

Synthesis of six member cyclic organic compounds.


Electrocyclic reaction where 4 π-electrons from the conjugated diene (anthracene) and 2 π-electrons from the dienophile (maleic anhydride) are involved in the reaction in the presence xylene as a solvent at temperature of 350 ⁰C. The driving force is the formation of new σ-bonds as they are energetically more stable than the π-bonds.

Learning Objectives (ILO’s)

  • Become proficient at running organic chemical reactions.

  • Learning basics of organic synthesis procedures.

  • Understand mechanism of Diels Alder reaction.

  • Learn function of Diels Alder reaction Get trained on how reflux and setup of reaction is used.

Theoretical Background/Context

The Diels-Alder reaction is one of the most important reactions of organic chemistry since they are used in synthesizing six-membered ringed cyclic organic compounds.

It is also considered as a [4+2]-cycloaddition reaction because it involves the an addition reaction between a conjugated diene molecule and a substituted alkene (dienophile) in order to produce a substituted cyclohexene system. 

Specifically, 4 π-electrons from the conjugated diene and 2 π-electrons from the dienophile are involved in the reaction. Therefore, it is counted as an electrocyclic reaction whose driving force is the formation of new σ-bonds as they are energetically more stable than the π-bonds.

Furthermore, Diels-Alder reaction is known as a non-polar reactions since no charged intermediates are formed during the reaction. In addition, no unpaired electrons are involved in the addition reaction. It is considered as a concerted reaction since several bonds are formed and broken simultaneously during the transition state.


Principle of Work

An example of Diels Alder reaction is the cycloaddition of anthracene (conjugated diene) and maleic anhydride (dienophile) to form 9,10-dihydroanthracene-9,10-endo-a3-succinic anhydride. Xylene is used as the reaction solvent due to its high-boiling that could accommodate the high temperature needed for running the chemical reaction. 
Maleic anhydride is known as a highly reactive dienophile owing to the presence of two electron withdrawing carbonyl substituents within its chemical structure. On the other hand, anthracene is not a highly reactive diene because of both its steric hindrance in addition to its high stability due to aromaticity. 

PraxiLabs is Recognized Worldwide

Customers Love PraxiLabs

“With the onset of the COVID-19 pandemic, we found ourselves in a situation that forced us to act quickly to find the best solution available to provide our students with a quality molecular genetics laboratory experience.”

Korri Thorlacius, B.Sc.
Biology Laboratory Instructor
Biology Department
Kwantlen Polytechnic University

'' Although there are now several vendors offering virtual reality software for physics labs, there is only one that offers a realistic, I feel like I’m in a real lab, solution: PraxiLabs.''

Dr.‌ ‌William‌ ‌H.‌ ‌Miner,‌ ‌Jr.‌ ‌
Professor‌ ‌of‌ ‌Physics‌ ‌
Palm‌ ‌Beach‌ ‌State‌ ‌College‌ ‌
Boca‌ ‌Raton,‌ ‌FL‌

" PraxiLabs offered my students a chance to actively engage with the material. Instead of watching videos on a topic, they could virtually complete labs and realize the practical applications of class topics. This is a quality alternative to in-person labs."

Crys Wright
Teaching Assistant
Texas A&M University, USA

"Great user experience and impressive interaction, I am very pleased to have tried the simulations and will continue to do so."

Dr. Khaled M Goher
Lecturer in Biomedical Engineering
Aston University, UK

The #1 Science Virtual Labs used by Educational Institutions

Explore More Interactive 3D Virtual Simulations

Designed for Safety and Engagement

Find out how PraxiLabs keeps students engaged and improves learning outcomes