Friedel–Crafts Acylation of Anisole Virtual Lab | PraxiLabs

Friedel–Crafts Acylation of Anisole Virtual Lab

Chemistry | Organic Chemistry

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General Aim

Alkylation and acylation of aromatic rings


Friedel crafts reaction is used for either alkylation or acylation of aromatic rings through electrophilic substitution reaction.

Learning Objectives (ILO’s)

  • <p>Become proficient at running organic chemical reactions.

  • Learning basics of organic synthesis procedures.

  • Understand the mechanism of Friedel Crafts reaction.

  • Learn the function of Friedel Crafts reaction.

  • Get trained on how reflux and setup of reaction is used.</p>

Theoretical Background/Context

Friedel Crafts reaction is an example of electrophilic substitution reactions that can be carried out for aromatic compounds. Substitution of either an alkyl group ( - CH2- R) or an acyl group ( - CO – CH2 – R) takes place leading to the formation of a new carbon – carbon bond. During this reaction, aluminium .chloride is used as a catalyst, where it reacts with acetyl chloride or acetic anhydride forming acylium ion (+CO – CH3) as a charged electrophile

Figure 1. Acylation of anisole


Mechanism of Friedel Crafts reaction:


Principle of Work

Acylation of anisole is carried out through Friedel Crafts reaction, where aluminum chloride is used as a catalyst.

Then, the formed product is extracted using a separatory funnel. Finally, magnesium sulfate is used as a dehydrating agent for the organic layer before evaporating dichloromethane to obtain the final product.

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