GC/MS Analysis Virtual Lab Simulation | PraxiLabs

GC/MS Analysis Virtual Lab Simulation

Chemistry | Analytical Chemistry

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GC/MS Analysis Virtual Lab

General Aim of GC/MS Analysis Experiment

Pesticide analysis in water samples by GC-MS


GC/MS Analysis Method

An environmental water sample containing a combination of pesticides will be analyzed using GC/MS instrument. GC/MS analysis steps: GC/MS analysis steps: First, the pesticides will be extracted from the water sample through solid phase extraction setup. Then, the extract will be dried purified and solubilized again in specific solvent to be compatible with GC/MS instrument. Afterwards, GC will be used to detect the number of pesticides as well as their relative abundance and retention time. Finally, mass spectrometry will be used to detect the m/z of each component to predict its chemical structure along with other characterization techniques.

Learning Objectives of GC/MS Analysis Experiment

  • <p>Become proficient at basic concepts of water samples analysis.

  • Learning basics of chromatographic techniques.

  • Understand mechanism of operation of GC/MS.

  • Learn functions of GC and MS in water sample analysis.

  • Get trained on using the instruments and their software.</p>

GC/MS Analysis Theory

Pesticide residue analysis is carried out through several steps, e. g. extraction from sample matrix, clean up and final chromatographic separation and determination. Thus, environmental water samples cannot be analyzed without some preliminary sample preparation. Solid phase extraction “SPE” is considered one of the most reliable techniques that could be used for pesticide residues isolation from environmental water samples. This returns back to that it is fast, cost effective, accurate, and precise. In addition, it consumes small volume of organic solvent in addition to being easily adapted for field work. 
The other most widely used methods for the analysis of pesticides in water are based on “Gas Chromatography” (GC) and Liquid Chromatography” (LC). However, identification based only on chromatographic analysis (retention time) without the use of spectrometric detection is not suitable as confirmatory method. Therefore, “Mass spectrometry” (MS) connected to GC “GC/MS” was found to be indispensable for high sensitivity and unambiguous detection, confirmation and determination of such residues in different matrices. GC-MS is a counted as a very efficient technique with a high resolution power for variety of compounds including but not limited to volatile and semi-volatile compounds.

GC- MS Analysis Principle

Water sample containing a combination of different pesticides is analysed through GC coupled MS instrument (GC/MS Analysis). GC is used to detect the number of compounds through detecting their elution time versus their relative abundance. Then each compound is further analysed using mass spectrometry to detect their chemical structure.

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